Prolifererande verrukös leukoplaki, PVL, är en ovanlig sjukdom som yttrar sig genom multipla, vita förändringar i munslemhinnan som recidiverar och med tiden riskerar att utvecklas till cancer. Diagnosen kan endast ställas kliniskt när sjukdomsförloppet pågått under lång tid och det finns heller inga effektiva behandlingsmetoder. Etiologin till sjukdomen är okänd, men idag vet man att det finns ett samband mellan cancerutveckling och vissa virustyper. Syftet med studien är att undersöka om det går att påvisa humant papillom virus, HPV, i vävnadsprover från patienter som kan misstänkas ha PVL. Urvalet bestod av 11 patientfall, där vävnadsprover från biobanken vid avdelningen för oral patologi, Malmö högskola, samlats in och studerats med kromogen in situ hybridisering. Resultaten visade en högre förekomst av HPV i biopsier tagna i det senare skedet av sjukdomen jämfört med tidigare biopsier.

This study investigated whether in-situ audiometry, delivered via hearing aids, is a better option as a basis forprescribing hearing aid amplification, compared to conventional audiometry. By examining the real ear insertgain (REIG) in 29 ears (18 subjects), that had been fitted with a hearing aid programmed using both conventionalaudiometry and in-situ audiometry, the study looked at whether in-situ audiometry based prescription is closer tothe NAL NL1's fitting target than audiogram based prescription. The hearing aid Siemens Pure 7mi with speakerunit M was used on all participants. The results showed how in-situ audiometry based gain at certain frequenciesis more consistent with the target curve, especially at 1000, 1500, 2000 and 4000 Hz. It was not establishedwhether the findings of the study were statistically significant.

This study investigated whether in-situ audiometry, delivered via hearing aids, is a better option as a basis forprescribing hearing aid amplification, compared to conventional audiometry. By examining the real ear insertgain (REIG) in 29 ears (18 subjects), that had been fitted with a hearing aid programmed using both conventionalaudiometry and in-situ audiometry, the study looked at whether in-situ audiometry based prescription is closer tothe NAL NL1's fitting target than audiogram based prescription. The hearing aid Siemens Pure 7mi with speakerunit M was used on all participants. The results showed how in-situ audiometry based gain at certain frequenciesis more consistent with the target curve, especially at 1000, 1500, 2000 and 4000 Hz. It was not establishedwhether the findings of the study were statistically significant.

Lindberg M & Lindstrii F. PVK in situ. En observationsstudie av följsamhet till riktlinjer gällande skötsel, dokumentation vid fixeringsförband, komplikationssymptom samt tid in situ. Examensarbete i omvårdnad 15 högskolepoäng. Malmö högskola: Fakulteten för hälsa och samhälle, institutionen för vårdvetenskap, 2014. Bakgrund: perifer ven kateter (PVK) är ett mycket vanligt ingrepp inom sjukvården som medför risker för kateterrelaterade komplikationer.

Today's high oil prices and more stringent environmental requirements have led to that manufacturers of mobile construction equipment try to make their products more energy efficient. With this in mind a project about hybridization of hydraulic systems has been formed. The purpose of this project was to analyze the savings that can be achieved by hybridization of hydraulic systems. A reach stacker truck (Kalmar DRD450-80S4XS) were simulated in some load cases with conventional hydraulic systems and with three types of hybridized hydraulic systems. Different parts of the hydraulic systems were also analyzed separately.

In situ sekvensering är en metod som kan användas för att lokalisera differentiellt uttryck av mRNA direkt i vävnadssnitt, vilket kan ge viktiga ledtrådar om många sjukdomstillstånd. Idag förloras många av sekvenserna från in situ sekvensering på grund av det kvalitetsmått man använder för att säkerställa att sekvenser är korrekta. Det finns troligtvis möjlighet att förbättra prestandan av den nuvarande base calling-metoden eftersom att metoden är i ett tidigt utvecklingsskede. Vi har genomfört explorativ dataanalys för att undersöka förekomst av systematiska fel och korrigerat för dessa med hjälp av statistiska metoder. Vi har framförallt undersökt tre metoder för att korrigera för systematiska fel:I) Korrektion av överblödning som sker på grund avöverlappande emissionsspektra mellan fluorescenta prober.II) En sannolikhetsbaserad tolkningav intensitetsdata som resulterar i ett nytt kvalitetsmått och en alternativ klassificerare baseradpå övervakad inlärning.III) En utredning om förekomst av cykelberoende effekter, exempelvisofullständig dehybridisering av fluorescenta prober.Vi föreslår att man gör följande saker:Implementerar och utvärderar det sannolikhetsbaserade kvalitetsmåttetUtvecklar och implementerar den föreslagna klassificerarenGenomför ytterligare experiment för att påvisa eller bestrida förekomst av ofullständigdehybridisering.

Denna studie undersöker hur stressfaktorer påverkar kroppen vid dykning i gruva. Undersökningen genomfördes under en helgs intensivt dykande, för att bestämma lungkapacitet, pulsnivå samt eventuell vätske- och viktförlust hos dykarna. Testerna bestod av vägning, spirometritester och pulsmätningar. Testpersonerna dök mellan ett till tre dyk under helgen. Två av det totala antalet dyk var på 74 meters djup, resterande dyk genomfördes på 36 meters djup.

The earmould acoustics affect the amplification that the hearing aid is programmed to give to its user. It is therefore important that the choices made for the earmould are correctly done. One choice is regarding the shape of the soundbore that affects the frequency response of the hearing aid above a certain cut-off frequency. The purpose of this project was to measure the frequency response when altering the shape of the soundbore in the earmould. Additionally, the aim was to examine how the frequency response is affected when the shape of the soundbore is not set or is not possible to set in the software when programming the hearing aid.

A common way to stabilize high rise buildings is to use an elevator core built of concrete. Today, we use to build these elevator cores of in-situ concrete. Precast concrete twin wall (double wall) is a semi-finished product that has become more common in recent years. This diploma work studies how the twin wall works out as structural elements in an elevator core. The work also shows some possible ways of designing twin walls and highlights some important parts of the design that will be vital to the stability of the building.    The result shows that it is important to think through where the element joints should be placed.

The aim of this master thesis was to examine a possible connection between chromatin functions and the DNA damage repair system, with the imprinted IGF2/H19 locus as a bait. Interactions can occur within and between chromosomes and it has been shown that H19 ICR on both alleles can communicate with alleles on other chromosomes. The methylation-sensitive insulator protein CTCF is bound on the maternal H19 ICR and acts as an insulator by blocking the IGF2 promoter to access its enhancers. This is possible by formation of loop structures by CTCF that enables intra and inter-chromosomal interactions. CTCF is poly(ADP-ribosyl)ated by PARP-1 when it is bound to H19 ICR.

Under september månad år 1995 påbörjades utläggningen av jordmaterial för den provbank vilken upprättades då Öresundsbron skulle byggas. I detta fullskaleförsök kontrollerades massorna genom olika sonderingsmetoder och även sättningarnas utveckling. Uppbyggda för provbanken var en höjd på 4,5 m och själva försöksområdet hade en längd på 40 m och en bredd på 9 m. I detta arbete har syftet varit att studera provbanken i Petersborg och jämföra de uppmätta sättningarna mot de numeriska simuleringarna. De numeriska modeller som har skapats i finita elementprogrammet PLAXIS är baserade på de utförda geotekniska undersökningarna.

Totally 84 differentially expressed mRNA clones from infective L3 larvae of the parasite Haemonchus contortus, a blood sucking nematode, were analyzed with single strand hybridization assay (SSH). Altogether 79 clones were sequenced, edited, and compared with proteins found via BLAST in GeneBank. The aim was to investigate gene expression and potential protein expression following storage at 5 °C for 32 weeks. mRNA was extracted from fresh and stored L3. The SSH derived products were cloned into E.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Breast cancer is the most common tumor disease among women in Sweden. About 7000persons, having a median age of 65, are diagnosed each year with this disease. Withmammography screening, breast cancer can be detected in an early stage which improves theoverall survival (OS). 20-30 % of the breast cancer tumors are overexpressing humanepidermal growth factor receptor 2 (HER2), which is a protein that stimulates cell proliferation.Trastuzumab (Herceptin®) is a humanised monoclonal antibody that targets the HER2-proteinand prevent the signals for cell proliferation.Trastuzumab has earlier been used for treatment of metastatic breast cancer. In the year of 2007trastuzumab was approved for adjuvant treatment of patients who has been medicated withsurgery and/or radiation.The aim of this study was to investigate the effects of adjuvant treatment with trastuzumab inHER2-positive breast cancer patients.

Young women with immigrant background are generally looked upon as victims of patriarchal structures and cultural determinism.The purpose of this bachelor thesis was therefore to have a salutogen perspective. We investigated how young women with a transcultural background are affected by and how they use their experiences from different backgrounds in their creating of identity.We based our essay on qualitative interviews and current research on the subjects of multi culture, identity and youth. The interviewees were seven young women with experience of multi cultural background and performing different kind of artistic activity.The theory and empirical material combined and compared resulted in three themes: affinity, cultural hybridization, and salutogen factors.We saw that for those young women affinity functioned as a basis for creating identity and that their double background enriches them in several aspects. The three major salutogen factors that the interviewees had in common, and we emphasize, are their struggle, open mind and awareness of freedom.The global youth culture has a great impact upon the young women and to some extent we could recognize cultural hybridization. We consider this neglected subject urgent and very relevant for social work in the multi cultural society of Sweden..